Anti-inflammatory activity of calcium channel blocker lercanidipine hydrochloride
نویسندگان
چکیده
منابع مشابه
Anti-inflammatory Activity of Calcium Channel Blockers
Objective: To explore the anti-inflammatory activity of calcium channel blockers. Material and Methods: The anti-inflammatory activity was determined by producing inflammation in rats of either sex. Acute inflammation was produced by injecting carrageenan, formalin and histamine in hindpaw of rats. For sub-acute inflammation the cotton pellets granuloma method was employed. Formaldehyde induced...
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Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
متن کاملEvaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker
Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
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1522-8401/$ see fro doi:10.1016/j.cpem.2 Department of Eme Children’s Hospit RI 02903, USA. Reprint requests and Department of E Children’s Hospit RI 02903, USA. Calcium-channel blockers (CCB) were first developed in the 1960s. Since then, the list of formulations and variety of uses has increased significantly. Unfortunately, toxic exposures to CCBs have also increased since their debut. This ...
متن کاملNatriuretic action of manidipine hydrochloride, a new calcium channel blocker, in spontaneously hypertensive rats.
Effects of manidipine, a new dihydropyridine derivative, on sodium and water excretion were examined in conscious spontaneously hypertensive rats. Manidipine (3 mg/kg) significantly increased the sodium and water excretion in the urine collected for 3 hr after the calcium antagonist was orally administered, and its natriuretic action was more prominent than those of nifedipine and nicardipine (...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Pharmacotherapeutics
سال: 2013
ISSN: 0976-500X
DOI: 10.4103/0976-500x.119707